Below please find all papers generated by the Lead Identification Division and its scientific staff.  If an article is available for viewing in PubMed, clicking on the PubMed ID (PMID) number for the relevant article will direct you to the appropriate viewing website.

There are currently 159 papers that have been either published or accepted.

159 – Smith E, Dickson L, Pickford P, Rowland A, Shumate J, Perez K, Scampavia L, Hernandez D, Spicer T.
Protocol for Kinetic Mode Potassium Channel Assays on Common Plate Readers and Microscopes
arrowSLAS Discovery.  2024 March.

158 – Aziz F, Reddy K, Fernandez-Vega V, Dey R, Hicks K, Rao S, Ortiz L, Smith E, Shumate J, Scampavia L, Carpino N, Spicer T, French J.
Rebamipide and Derivatives are Potent, Selective Inhibitors of Histidine Phosphatase Activity of the Suppressor of T Cell Receptor Signaling Proteins
arrowJournal of Medicinal Chemistry.  2024 January. 38252624

157 – Ortiz L, Fernandez-Vega V, Shumate J, Peles A, Zeiger J, Scampavia L, Spicer T.
Protocol for High Throughput 3D Drug Screening of Patient Derived Melanoma and Renal Cell Carcinoma
arrowSLAS Discovery.  2024 January. 38218316

156 – Coant N, Bickel JD, Rahaim R, Otsuka Y, Choi Y, Xu R, Simoes M, Cariello C, Mao C, Saied EM, Arenz C, Spicer TP, Bannister TD, Tonge PJ, Airola MV, Scampavia L, Hannun Y, Rizzo RC, Haley JD.
Neutral ceramidase-active site inhibitor chemotypes and binding modes
arrowBioorganic Chemistry.  2023 October. 37531819

155 – Lee E, Archasappawat S, Ji K, Pena J, Fernandez-Vega V, Gangaraju R, Beesabathuni NS, Kim MJ, Tian Q, Shah P, Scampavia L, Spicer T, Hwang CI
A new vulnerability to BET inhibition due to enhanced autophagy in BRCA2 deficient pancreatic cancer
arrowCell Death & Disease.  2023 September. 37398312

154 – Rajan RG, Fernandez-Vega V, Sperry J, Nakashima J, Do LH, Andrews W, Boca S, Islam R, Chowdhary SA, Seldin J, Souza GR, Scampavia L, Hanafy KA, Vrionis FD, Spicer TP
In Vitro and In Vivo Drug-Response Profiling Using Patient-Derived High-Grade Glioma
arrowCancers.  2023 June. 37444398

153 – Hou S, Li Z, Chen X, Wang W, Duan T, Scampavia L, Yuan Y, Spicer TP, Chen X, Xie T
Elemene sensitizes pancreatic cancer cells to bortezomib by enhancing proteasome inhibition via molecular patch mechanism
arrowNature – Signal Transduction and Targeted Therapy.  2023 February. 36849489

152 – Liao GY, Xu H, Shumate J, Scampavia L, Spicer T, Xu B
High throughput assay for compounds that boost BDNF expression in neurons
arrowSLAS Discovery.  2023 February. 36842668

151 – Fernandez-Vega V, Yang D, Jordán LO, Ye F, Conway L, Chen LY, Shumate J, Baillargeon P, Scampavia L, Souza G, Parker C, Shen B, Spicer TP
Protocol for 3D Screening of Lung Cancer Spheroids using Natural Products
arrowSLAS Discovery.  2023 January. 36681384

150 – Liu Z, Chen K, Dai J, Xu P, Sun W, Liu W, Zhao Z, Bennett SP, Li P, Ma T, Lin Y, Kawakami A, Yu J, Wang F, Wang C, Li M, Chase P, Hodder P, Spicer TP, Scampavia L, Cao C, Pan L, Dong J, Chen Y, Yu B, Guo M, Fang P, Fisher DE, Wang J
A unique hyperdynamic dimer interface permits small molecule perturbation of the melanoma oncoprotein MITF for melanoma therapy.
arrowNature – Cell Research.  2023 January. 36588115

149 – Smith E, Davis-Gardner ME, Garcia-Ordonez RD, Nguyen TT, Hull M, Chen E, Yu X, Bannister TD, Baillargeon P, Scampavia L, Griffin P, Farzan M, Spicer TP
High Throughput Screening for Drugs that Inhibit 3C-Like Protease in SARS-CoV-2
arrowSLAS Discovery.  2023 January. 36646172

148 – Reed A, Ichu TA, Milosevich N, Melillo B, Schafroth MA, Otsuka Y, Scampavia L, Spicer TP, Cravatt BF
LPCAT3 Inhibitors Remodel the Polyunsaturated Phospholipid Content of Human Cells and Protect from Ferroptosis.
arrowACS Chem Biol.  2022 June. 35658397

147 – Moghadasi SA, Esler MA, Otsuka Y, Becker JT, Moraes SN, Anderson CB, Chamakuri S, Belica C, Wick C, Harki DA, Young DW, Scampavia L, Spicer TP, Shi K, Aihara H, Brown WL, Harris RS
Gain-of-Signal Assays for Probing Inhibition of SARS-CoV-2 Mpro/3CLpro in Living Cells.
arrowmBio  2022 April. 35471084

146 – Souza G, Spicer TP
SLAS special issue editorial 2022: 3D cell culture approaches of microphysiologically relevant models
arrowSLAS Discovery.  2022 Mar. 35339725

145 – Smith E, Campbell S, Wilson A, Shumate J, Baillargeon P, Scampavia L, Kamenecka T, Spicer TP, Solt L
High throughput screening for compounds to the orphan nuclear receptor NR2F6
arrowSLAS Discovery.  2022 Mar. 35331960

144 – Fernandez-Vega V, Hou S, Plenker D, Tiriac H, Baillargeon P, Shumate J, Scampavia L, Seldin J, Souza G, Tuveson D, Spicer TP
Lead Identification using 3D Models of Pancreatic Cancer
ArrowSLAS Discovery.  2022 Mar. 35306207

143 – Rajendra Rao S, Kostic A, Baillargeon P, Fernandez-Vega V, Rios de Anda M, Fletcher K, Shumate J, Scampavia L, Buxbaum J, Spicer TP
Screening for Modulators of Autism Spectrum Disorder Using Induced Human Neurons
arrowSLAS Discovery.  2022 Feb. 35123134

142 – Baillargeon P, Fernandez-Vega V, Ortiz L, Shumate J, Marques N, Deng L, Spicer TP, Scampavia L
Rapid Deployment of Inexpensive Open-Source Orbital Shakers in Support of High-Throughput Screening
arrowSLAS Technology.  2022 Jan. 35066236

141 – Chulkov E, Smith E, Rohr C, Yahya N, Park S, Scampavia L, Spicer TP, Marchant J
Identification of novel modulators of a schistosome transient receptor potential channel targeted by praziquantel
arrowPLoS Negl Top Dis.  2021 Nov. 34731172

140 – Mediouni S, Mou H, Otsuka Y, Jablonski J, Adcock R, Batra L, Chung D, Rood C, S. de Vera I, Rahaim Jr. R, Ullah S, Yu X, Getmanenko Y, Kennedy N, Wang C, Nguyen T, Hull M, Chen E, Bannister T, Baillargeon P, Scampavia L, Farzan M, Valente S, Spicer TP
Identification of Potent Small Molecule Inhibitors of SARS-CoV-2 Entry
arrowSLAS Discovery<.  2021 October. 35058179

139 – Shirey R, Hart J, Sridharan B, Novick S, Turner L, Zhou B, Nielsen A, Eubanks L, Ueno L, Hixon M, Lairson L, Spicer TP, Scampavia L, Griffin P, Vogt P, Janda K
Synthetic fluorescent MYC probe: Inhibitor binding site elucidation and development of a high-throughput screening assay
arrowBioorganic & Medicinal Chemistry.  2021 July. 34130216

138 – Stoveken H, Fernandez-Vega V, Muntean B, Patil D, Shumate J, Bannister J, Scampavia L, Spicer TP, Martemyanov
Identification of Potential Modulators of the RGS7/G�5/R7BP Complex
arrowSLAS Discovery.  2021 June. 34112017

137 – Diez J, Rajendrarao S, Baajour S, Sripadhan P, Spicer TP, Scampavia L, Minond D
Development and Pilot Screen of Novel High Content Assay for Down Regulators of Expression of Heterogenous Nuclear Ribonuclear Protein H2
arrowCell Physiology & Biochemistry.  2021 May. 34014051

136 – Wang C, Diez J, Park H, Spicer TP, Scampavia L, Becker-Pauly C, Fields G, Minond D, Bannister T
Discovery and Optimization of Selective Inhibitors of Meprin a (Part II)
arrowPharmaceuticals.  2021 February. 33673639

135 – Hou S, Diez J, Wang C, Becker-Pauly C, Fields G, Bannister T, Spicer TP, Scampavia L, Minond D
Discovery and Optimization of Selective Inhibitors of Meprin a (Part I)
arrowPharmaceuticals.  2021 January. 33671080

134 – Spicer TP
Drug Discovery Targeting COVID-19
arrowSLAS Discovery.  2020 December. 33215959

133 – Smith E, Davis-Gardner M, Garcia-Ordonez R, Nguyen T, Hull M, Chen E, Baillargeon P, Scampavia L, Strutzenberg T, Griffin P, Farzan M, Spicer TP
High-Throughput Screening for Drugs That Inhibit Papain-Like Protease in SARS-CoV-2
arrowSLAS Discovery.  2020 October. 33043784

132 – Smith E, Dukovski D, Shumate J, Scampavia L, Miller J, Spicer TP
Identification of Compounds That Promote Readthrough of Premature Termination Codons in the CFTR
arrowSLAS Discovery.  2020 October. 33016182

131 – Llamosas N, Arora V, Vij R, Kilinc M, Bijoch L, Rojas C, Reich A, Sridharan B, Willems E, Piper D, Scampavia L, Spicer T, Miller C, Holder J, Rumbaugh G
SYNGAP1 Controls the Maturation of Dendrites, Synaptic Function, and Network Activity in Developing Human Neurons
arrowJournal of Neuroscience.  2020 September. 32887745

130 – Grandjean J, Madhavan A, Cech L, Seguinot B, Paxman R, Smith E, Scampavia L, Powers E, Cooley C, Plate L, Spicer T, Kelly J, Wiseman R
Pharmacologic IRE1/XBP1s activation confers targeted ER proteostasis reprogramming
arrowNature Chemical Biology.  2020 July. 32690944

129 – Otsuka Y, Airola M, Choi Y, Coant N, Snider J, Cariello C, Saied E, Arenz C, Bannister T, Rahaim R, Hannun Y, Shumate J, Scampavia L, Haley J, Spicer T
Identification of Small-Molecule Inhibitors of Neutral Ceramidase (nCDase) via Target-Based High-Throughput Screening
arrowSLAS Discovery.  2020 July. 32734807

128 – Smith E, Janovick JA, Bannister T, Shumate J, Ganapathy V, Scampavia L, Spicer T
Rescue of mutant gonadotropin-releasing hormone receptor function independent of cognate receptor activity
arrowNature Scientific Reports.  2020 June. 32601341

127 – Boca S, Bhuvaneshwar K, Fernandez-Vega V, Kancherla J, Rao S, Madhavan S, Riggins R, Beckman R, Bravo H, Scampavia L, Spicer T
Prioritizing targeted therapies in an evidence-based manner, integrating biological context and functional precision medicine
arrowJournal of Clinical Oncology.  2020 May.

126 – Wang L, Cheng C, Qin J, Xu M, Kao C, Shi J, You E, Gong W, Pedro-Rosa L, Chase P, Scampavia L, Madoux F, Spicer T, Hodder P, Xu H, Tsai S, Tsai M
Small-molecule inhibitor targeting orphan nuclear receptor COUP-TFII for prostate cancer treatment
arrowScience Advances.  2020 April. 32494682

125 – Pan C, Otsuka Y, Sridharan B, Woo M, Leiton C, Babu S, Goncalves M, Kawalerski R, Bai J, Change D, Biankin A, Scampavia L, Spicer T, Escobar-Hoyos L, Shroyer K
An Unbiased High-Throughput Drug Screen Reveals a Potential Therapeutic Vulnerability in the Most Lethal Molecular Subtype of Pancreatic Cancer
arrowMolecular Oncology.  2020 June. 32533886

124 – Pan C, Leiton C, Roa-Pena L, Kawalerski R, Moffitt R, Zhao J, Spicer T, Bailey P, Chang D, Biankin A, Duong T, Singh P, Shroyer K, Escobar-Hoyos L
Abstract C39: A novel rewired pathway of nucleotide metabolism drives chemoresistance in pancreatic cancer
arrowAACR Special Conference on Pancreatic CAncer: Advances in Science and Clinical Care.  2019 December.

123 – Perez O, Pena J, Fernandez-Vega V, Scampavia L, Spicer T
Drug Discovery and Development, Third Edition
arrowCRC Press.  2019 December.

122 – Baillargeon P, Spicer TP, Scampavia L
Applications for Open Source Microplate-Compatible Illumination Panels
arrowJoVE.  2019 October. PMID:31633701

Applications for Open Source Microplate-Compatible Illumination Panels
121 – Baillargeon P, Shumate J, Hou S, Fernandez-Vega V, Marques N, Souza G, Seldin J, Spicer TP, Scampavia L
Automating a Magnetic 3D Spheroid Model Technology for High-Throughput Screening
arrowSLAS Technology.  2019 June. PMID:31225974

120 – Sridharan B, Hubbs C, Llamosas N, Kilinc M, Singhera F, Willems E, Piper D, Scampavia L, Rumbaugh G, Spicer TP
A Simple Procedure for Creating Scalable Phenotypic Screening Assays in Human Neurons
arrowNature Scientific Reports.  2019 June. PMID:31227747

119 – Morgan G, Yan N, Mortenson D, Rennella E, Blundon J, Gwin R, Lin C, Stanfield R, Brown S, Rosen H, Spicer TP, Fernandez-Vega V, Merlini G, Kay L, Wilson I, Kelly J
Stabilization of amyloidogenic immunoglobulin light chains by small molecules
arrowPNAS.  2019 April. PMID:30971495

118 – Zhou W, Yin Y, Smith E, Chou J, Shumate J, Scampavia L, Spicer TP, Carpino N, French JB
Discovery and Characterization of Two Classes of Selective Inhibitors of the Suppressor of the TCR Signaling Family of Proteins
arrowACS Infect Dis.  2019 Feb. PMID:30485744

117 – Baillargeon P, Coss-Flores K, Singhera F, Shumate J, Williams H, DeLuca L, Spicer TP, Scampavia L
Design of Microplate-Compatible Illumination Panels for a Semiautomated Benchtop Pipetting System
arrowSLAS Technology.  2019 January. PMID:30698997

116 – Baillargeon P, Fernandez-Vega V, Sridharan B, Brown S, Griffin P, Rosen H, Cravatt B, Scampavia L, Spicer TP
The Scripps Molecular Screening Center and Translational Research Institute
arrowSLAS Discovery.  2019 January. PMID:30682260

115 – Spicer TP, Fernandez-Vega V, Scampvia L, Willetts L, Vessels M
A Novel 3D Culture System for High-Throughput Hepatoxicity Screening
arrowBioProcess International.  2018 October. PMID:

114 – Spicer TP, Gardiner DL, Schoenen FJ, Roy S, Griffin PR, Chase P, Scampavia L, Hodder P, Trenholme KR
Identification of Antimalarial Inhibitors Using Late-Stage Gametocytes in a Phenotypic Live/Dead Assay
arrowSLAS Discovery.  2018 August. PMID:30142014

113 – Janovick JA, Spicer TP, Bannister TD, Smith E, Ganapathy V, Scampavia L
Chemical Validation and Optimization of Pharmacoperones Targeting Vasopressin Type 2 Receptor Mutant
arrowBiochem J.  2018 August. PMID:30068530

112 – Nieto A, Fernandez-Vega V, Spicer TP, Sturchler E, Adhikari P, Kennedy N, Mandat S, Chase P, Scampavia L, Bannister T, Hodder P, McDonald PH
Identification of Novel, Structurally Diverse, Small Molecule Modulators of GPR119
arrowAssay Drug Dev Technol.  2018 July. PMID:30019946

111 – Quereda V, Hou S, Madoux F, Scampavia L, Spicer T, Duckett D
A Cytotoxic Three-Dimensional-Spheroid, High-Throughput Assay Using Patient-Derived Glioma Stem Cells
arrowSLAS Discovery.  2018 May. PMID:29750582

110 – Kota S, Hou S, Guerrant W, Madoux F, Troutman S, Fernandez-Vega V, Alekseeva N, Madala N, Scampavia L, Kissil J, Spicer T
A novel three-dimensional high-throughput screening approach identifies inducers of a mutant KRAS selective lethal phenotype
arrowOncogene.  2018 May. PMID:29743592

109 – Muntean BS, Patil DN, Madoux F, Fossetta J, Scampavia L, Spicer T, Martemyanov KA
A High-Throughput Time-Resolved Fluorescence Energy Transfer Assay to Screen for Modulators of RGS7/GB5/R7BP Complex
arrowAssay Drug Dev Technol.  2018 Apr. PMID:29658790

108 – Hou S, Tiriac H, Sridharan B, Scampavia L, Madoux F, Seldin J, Souza G, Watson D, Tuveson D, Spicer T
Advanced Development of Primary Pancreatic Organoid Tumor Models for High-Throughput Phenotypic Drug Screening
arrowSLAS Discovery.  2018 Apr. PMID:29673279

107 – Shumate J, Baillargeon P, Spicer T, Scampavia L
IoT for Real-Time Measurement of High-Throughput Liquid Dispensing in Laboratory Environments
arrowSLAS Technology.  2018 Apr. PMID:29649373

106 – Wolff R, Wang-Gillam A, Alvarez H, Tiriac H, Engle D, Hou S, Groff A, San Lucas A, Bernard V, Allenson K, Castillo J, Kim D, Mulu F, Huang J, Stephens B, Wistuba I, Katz M, Varadhachary G, Park Y, Hicks J, Chinnaiyan A, Scampavia L, Spicer T, Gerhardinger C, Maitra A, Tuveson D, Rinn J, Lizee G, Yee C, Levine A
Dynamic changes during the treatment of pancreatic cancer.
arrowOncotarget.  2018 Feb. PMID:29599906

105 – Smith E, Giuliano KA, Shumate J, Baillargeon P, McEwan B, Cullen MD, Miller JP, Drew L, Scampavia L, Spicer TP
A Homogeneous Cell-Based Halide-Sensitive Yellow Fluorescence Protein Assay to Identify Modulators of the Cystic Fibrosis Transmembrane Conductance Regulator Ion Channel.
arrowAssay Drug Dev Technol.  2017 Nov. PMID:29172645

104 – Spicer T, Hubbs C, Vaissiere T, Collia D, Rojas C, Kilinc M, Vick K, Madoux F, Baillargeon P, Shumate J, Martemyanov K.A., Page D.T., Puthanveettil S, Hodder P, Davis R, Miller C.A., Scampavia L, Rumbaugh G
Improved Scalability of Neuron-Based Phenotypic Screening Assays for Therapeutic Discovery in Neuropsychiatric Disorders.
arrowMolecular Neuropsychiatry.  2017 Nov. PMID:29594133

103 – Singhera F, Cooper E, Scampavia L, Spicer T
Using bead injection to model dispensing of 3-D multicellular spheroids into microtiter plates.
arrowTalanta.  2017 Sep. PMID:29108585

102 – Kong J, Fang P, Madoux F, Spicer T, Scampavia L, Kim S, Guo M
High-Throughput Screening for Protein Synthesis Inhibitors Targeting Aminoacyl-tRNA Synthetases.
arrowSLAS Discovery.  2017 Oct. PMID:29020503

101 – Collia D, Bannister T, Tan H, Jin S, Langaee T, Shumate J, Scampavia L, Spicer T
A Rapid Phenotypic Whole-Cell Screening Approach for the Identification of Small-Molecule Inhibitors That Counter B-Lactamase Resistance in Pseudomonas aeruginosa.
arrowSLAS Discovery.  2017 Aug. PMID:28850797

100 – Janovick JA, Spicer TP, Scampavia L, Conn PM
Pharmacoperone rescue of vasopressin 2 receptor mutants reveals unexpected constitutive activity and coupling bias.
arrowPLoS One.  2017 Aug. PMID:28767678

99 – Powell K
Adding depth to cell culture.
arrowScience.  2017 Apr. PMID:

98 – Hou S, Madoux F, Scampavia L, Janovick JA, Conn PM, Spicer TP
Drug Library Screening for the Identification of Ionophores That Correct the Mistrafficking Disorder Associated with Oxalosis Kidney Disease.
arrowSLAS Discovery.  2017 Jan. PMID:28346094

97 – Madoux F, Tanner A, Vessels M, Willetts L, Hou S, Scampavia L, Spicer T.
A 1536-Well 3D Viability Assay to Assess the Cytotoxic Effect of Drugs on Spheroids.
arrowSLAS Discovery.  2017 Jan. PMID:28346088

96 – Madoux F, Dreymuller D, Pettiloud JP, Santos R, Becker-Pauly C, Ludwig A, Fields GB, Bannister T, Spicer TP, Cudic M, Scampavia LD, Minond D
Discovery of an enzyme and substrate selective inhibitor of ADAM10 using an exosite-binding glycosylated substrate.
 arrowSci Rep.  2016 Dec. PMID:27920432

95 – Wang J, Fang P, Chase P, Tshori S, Razin E, Spicer TP, Scampavia L, Hodder P, Guo M
Development of an HTS-Compatible Assay for Discovery of Melanoma-Related Microphthalmia Transcription Factor Disruptors Using AlphaScreen Technology.
 arrowJournal of Biomolecular Screening.  2016 Nov. PMID:27827304

94 – Swingle M, Volmar CH, Saldanha SA, Chase P, Eberhart C, Salter EA, D’Arcy B, Schroeder CE, Golden JE, Wierzbicki A, Hodder P, Honkanen RE
An Ultra-High-Throughput Screen for Catalytic Inhibitors of Serine/Threonine Protein Phosphatases Types 1 and 5 (PP1C and PP5C).
arrowJ Biomol Screen.  2016 Sept. PMID:27628691

93 – Plate L, Cooley CB, Chen JJ, Paxman RJ, Gallagher CM, Madoux F, Genereux JC, Dobbs W, Garza D, Spicer TP, Scampavia L, Brown SJ, Rosen H, Powers ET, Walter P, Hodder P, Weisman RL, Kelly JW.
Small molecule proteostasis regulators that reprogram the ER to reduce extracellular protein aggregation.
 arrowElife.  2016 Jul 20. PMID:27435961

92 – Janovick JA, Spicer TP,Smith E, Bannister TD, Kenakin T, Scampavia L, Conn PM.
Receptor antagonism/agonism can be uncoupled from pharmacoperone activity.
 arrowMol Cell Endocrinol.  2016 Jul 4. PMID:27389877

91 – Smith E, Janovick JA, Bannister TD, Shumate J, Scampavia L, Conn PM, Spicer TP.
Identification of Potential Pharmacoperones Capable of Rescuing the Functionality of Misfolded Vasopressin 2 Receptor Involved in Nephrogenic Diabetes Insipidus.
 arrowJournal of Biomolecular Screening.  2016 Jun 8. PMID:27280550

90 – Ewing H, Fernandez-Vega V, Spicer T, Chase P, Brown S, Scampavia L, Roush W, Riley S, Rosen H, Hodder P, Lambeau G, Gelb M.
Fluorometric High-Throughput Screening Assay for Secreted Phospholipases A2 Using Phospholipid Vesicles.
 arrowJournal of Biomolecular Screening.  2016 May 4. PMID:27146384

89 – Thenin-Houssier S, de Vera IM, Pedro-Rosa L, Brady A, Richard A, Konnick B, Opp S, Buffone C, Fuhrmann J, Kota S, Billack B, Pietka-Ottlik M, Tellinghuisen T, Choe H, Spicer T, Scampavia L, Diaz-Griffero F, Kojetin DJ, Valente ST.
Ebselen, a Small-Molecule Capsid Inhibitor of HIV-1 Replication
arrowAntimicrobial Agents and Chemotherapy.  2016 Mar. 25 PMID:26810656

88 – Jambrina E, Cerne R, Smith E, Scampavia L, Cuadrado M, Findlay J, Krambis M, Wakulchik M, Chase P, Brunavs M, Burris K, Gallagher P, Spicer T, Ursu D.
An Integrated Approach for Screening and Identification of Positive Allosteric Modulators of N-Methyl-D-Aspartate Receptors.
 arrowJournal of Biomolecular Screening.  2016 Feb 2. PMID:26838761

87 – Chase P, Enogieru I, Madoux F, Bishop E, Beer J, Scampavia L, Spicer T.
An Automated Miniaturized Method to Perform and Analyze Antimicrobial Drug Synergy Assays.
 arrowAssay and Drug Development Technologies.  2015 Dec 15. PMID:26669516

86 – Palde PB, Bhaskar A, Pedró Rosa LE, Madoux F, Chase P, Gupta V, Spicer T, Scampavia L, Singh A, Carroll KS. .
First-In-Class Inhibitors of Sulfur Metabolism with Bactericidal Activity against Non-Replicating M. tuberculosis.
 arrowACS Chem Biol.  2015 Nov 2. PMID:26524379

85 – Sanders MA, Madoux F, Mladenovic L, Zhang H, Ye X, Angrish M, Mottillo EP, Caruso JA, Halvorsen G, Roush WR, Chase P, Hodder P, Granneman JG.
Endogenous and Synthetic ABHD5 Ligands Regulate ABHD5-Perilipin Interactions and Lipolysis in Fat and Muscle.
 arrowCell Metab.  2015 Sep 22. PMID:26411340

84 – Abdul-Hay SO, Bannister TD, Wang H, Cameron MD, Caulfield TR, Masson A, Bertrand J, Howard EA, McGuire MP, Crisafulli U, Rosenberry TR, Topper CL, Thompson CR, Schurer SC, Madoux F, Hodder P, Leissring MA.
Selective targeting of extracellular insulin-degrading enzyme by quasi-irreversible thiol-modifying inhibitors.
 arrowACS Chem Biol.  2015 Sep 23. PMID:26398879

83 – Conn PM, Spicer TP, Scampavia L, Janovick JA.
Assay strategies for identification of therapeutic leads that target protein trafficking.
 arrowTrends Pharmacol Sci.  2015 Jun 8. PMID:26067100

82 – Schreiber S, Kotz J, Li M, Aube J, Austin C, Reed J, Rosen H, White E, Sklar L, Lindsley C, Alexander B, Bittker J, Clemons P, Souza A, Foley M, Palmer M, Shamji A, Wawer M, McManus O, Wu M, Zou B, Yu H, Golden J, Schoenen F, Simenov A, Jadhav A, JAckson M, Pinkerton A, Chung T, Griffin P, Cravatt B, Hodder P, Roush W, Roberts E, Chung D, Jonsson C, Noah J, Severson W, Ananthan S, Edwards B, Oprea T, Conn PM, Hopkins C, Wood M, Stauffer S, Emmitte K
Advancing Biological Understanding and Therapeutics Discovery with Small Moleucle Probes.
 arrowCell.  2015 Jun 4. PMID:26046436

81 – Smith E, Chase P, Niswender C, Utley T, Sheffler D, Noetzel M, Lamsal A, Wood M, Conn PJ, Lindsley C, Madoux F, Acosta M, Scampavia L, Spicer T, Hodder P.
Application of Parallel Multiparametric Cell-Based FLIPR Detection Assays for the Identification of Modulators of the Muscarinic Acetylcholine Receptor 4 (M4).
 arrowJ Biomol Screen.  2015 Apr 16. PMID:25877150

80 – Chang J, Zuhl A, Speers A, Niessen S, Brown S, Mulvihill M, Spicer TP, Southern M, Scampavia L, Fernandez-Vega V, Ferguson J, Dix M, Hodder P, Rosen H, Nomura D, Kwon O, Hsu K-L, Cravatt B.
A selective inhibitor of platelet-activating factor acetylhydrolases 1b2 and 1b3 that impairs cancer cell survival.
 arrowACS Chem Biol.  2015 Jan 20. PMID:25602368

79 – Madoux F, Janovick JA, Smithson D, Fargue S, Danpure CJ, Scampavia L, Chen YT, Spicer TP, Conn PM.
Development of a Phenotypic High-Content Assay to Identify Pharmacoperone Drugs for the Treatment of Primary Hyperoxaluria Type 1 by High-Throughput Screening
arrowAssay Drug Dev Technol.  2015 January/February;13(1):16-24. PMID:25710543

78 – Wang Y, Stowe RL, Pinello CE, Tian G, Madoux F, Li D, Zhao LY, Li JL, Wang Y, Wang Y, Ma H, Hodder P, Roush WR, Liao D
Identification of Histone Deacetylase Inhibitors with Benzoylhydrazide Scaffold that Selectively Inhibit Class I Histone Deacetylases
arrowChem Biol.  2015 Feb 19;22(2):273-84. doi: 10.1016/j.chembiol.2014.12.015. PMID:25699604

77 – Cameron M, Kamenecka T, Madoux F, Chase P, Roush W, Hodder P
ML368 Identification of Imidazopyridines as Selective Inhibitors of the Cytochrome P450 Enzyme CYP3A4
arrowProbe Reports from the NIH Molecular Libraries Program.   PMID:21433368

76 – Zhao N1, Darby CM, Small J, Bachovchin DA, Jiang X, Burns-Huang KE, Botella H, Ehrt S, Boger DL, Anderson ED, Cravatt BF, Speers AE, Fernandez-Vega V, Hodder PS, Eberhart C, Rosen H, Spicer TP, Nathan CF
Target-Based Screen Against a Periplasmic Serine Protease That Regulates Intrabacterial pH Homeostasis in Mycobacterium tuberculosis
arrowACS Chem Biol.  2014 Dec 5. [Epub ahead of print].  PMID:25457457

75 – Kadakkuzha BM, Spicer TP, Chase P, Richman JB, Hodder P, Puthanveettil SV.
High-throughput screening for small molecule modulators of motor protein Kinesin.
 arrowAssay Drug Dev Technol.  2014 Oct. PMID:25383721

74 – Timothy P. Spicer, Jianwen Jiang, Alexander B. Taylor, Jun-Yong Choi, P. JohnHart, William R. Roush, Gregg B. Fields, Peter S. Hodder, and Dmitriy Minond
Characterization of Selective Exosite-Binding Inhibitors of Matrix Metalloproteinase 13 That Prevent Articular Cartilage Degradation In Vitro
arrow J Medicinal Chemistry.  2014 Oct 20. [Epub ahead of print].  PMID:25330343

73 – Pedró-Rosa L, Buckner FS, Ranade RM, Eberhart C, Madoux F, Gillespie JR, Koh CY, Brown S, Lohse J, Verlinde CL, Fan E, Bannister T, Scampavia L, Hol WG, Spicer T, Hodder P
Identification of Potent Inhibitors of the Trypanosoma brucei Methionyl-tRNA Synthetase via High-Throughput Orthogonal Screening
arrow J Biomol Screen.  2014 Aug 27. pii: 1087057114548832. [Epub ahead of print].  PMID: 25163684

72 – Gentry PR, Kokubo M, Bridges TM, Noetzel MJ, Cho HP, Lamsal A, Smith E, Chase P, Hodder PS, Niswender CM, Daniels JS, Conn PJ, Lindsley CW, Wood MR
Development of a Highly Potent, Novel M5 Positive Allosteric Modulator (PAM) Demonstrating CNS Exposure: 1-((1H-indazol-5-yl)sulfoneyl)-N-ethyl-N-(2-(trifluoromethyl)benzyl)piperidine-4-carboxamide (ML380)
arrowJ Med Chem.  2014 Aug 22. [Epub ahead of print].  PMID: 25147929

71 – Madoux F, Tredup C, Spicer TP, Scampavia L, Chase PS, Hodder PS, Fields GB, Becker-Pauly C, Minond D
Development of HTS assays and pilot screen for inhibitors of metalloproteases meprin α and β
arrowBiopolymers.  2014 Jul 21. doi: 10.1002/bip.22527. [Epub ahead of print].  PMID: 25048711

70 – Conn PM, Smith E, Spicer T, Chase P, Scampavia L, Janovick JA
A phenotypic high throughput screening assay for the identification of pharmacoperones for the gonadotropin releasing hormone receptor
arrow Assay Drug Dev Technol.  2014 May;12(4):238-46. doi: 10.1089/adt.2014.576.  PMID: 24831790

69 – Sturchler E, Chen W, Spicer T, Hodder P, McDonald P, Duckett D
Development of an HTS-Compatible Assay for the Discovery of ASK1 Signalosome Inhibitors Using AlphaScreen Technology
arrowAssay Drug Dev Technol.  2014 May;12(4):229-37. doi: 10.1089/adt.2013.558.  PMID: 24831789

68 – Penas C, Ramachandran V, Simanski S, Lee C, Madoux F, Rahaim RJ, Chauhan R, Barnaby O, Schurer S, Hodder P, Steen J, Roush WR, Ayad NG
Casein Kinase 1δ Dependent Wee1 Degradation
arrowJ Biol Chem.  2014 Jul 4;289(27):18893-18903. Epub 2014 May 9.  PMID: 24817118

67 – Yan F, Yu Y, Chow DC, Palzkill T, Madoux F, Hodder P, Chase P, Griffin PR, O’Malley BW, Lonard DM
Identification of verrucarin a as a potent and selective steroid receptor coactivator-3 small molecule inhibitor
arrow PLoS One.  2014 Apr 17;9(4):e95243. doi: 10.1371/journal.pone.0095243. eCollection 2014.  PMID: 24743578

66 – Gentry PR, Kokubo M, Bridges TM, Cho HP, Smith E, Chase P, Hodder PS, Utley TJ, Rajapakse A, Byers F, Niswender CM, Morrison RD, Daniels JS, Wood MR, Conn PJ, Lindsley CW
Discovery, Synthesis and Characterization of a Highly Muscarinic Acetylcholine Receptor (mAChR)-Selective M5 -Orthosteric Antagonist, VU0488130 (ML381): A Novel Molecular Probe
arrow ChemMedChem.  2014 Aug;9(8):1677-82. doi: 10.1002/cmdc.201402051. Epub 2014 Apr 1.  PMID: 24692176

65 – Spicer T, Fernandez-Vega V, Chase P, Scampavia L, To J, Dalton JP, Da Silva FL, Skinner-Adams TS, Gardiner DL, Trenholme KR, Brown CL, Ghosh P, Porubsky P, Wang JL, Whipple DA, Schoenen FJ, Hodder P
Identification of Potent and Selective Inhibitors of the Plasmodium falciparum M18 Aspartyl Aminopeptidase (PfM18AAP) of Human Malaria via High-Throughput Screening
arrow J Biomol Screen.  2014 Mar 11. [Epub ahead of print].  PMID: 24619116

64 – Lewallen DM, Bicker KL, Madoux F, Chase P, Anguish L, Coonrod S, Hodder P, Thompson PR
A FluoPol-ABPP PAD2 High-Throughput Screen Identifies the First Calcium Site Inhibitor Targeting the PADs
arrow ACS Chem Biol.  2014 Apr 18;9(4):913-21. doi: 10.1021/cb400841k. Epub 2014 Jan 27.  PMID: 24467619

63 – Wang Y, Lonard DM, Yu Y, Chow DC, Palzkill TG, Wang J, Qi R, Matzuk AJ, Song X, Madoux F, Hodder P, Chase P, Griffin PR, Zhou S, Liao L, Xu J, O’Malley BW
Bufalin is a potent small molecule inhibitor of the steroid receptor coactivators SRC-3 and SRC-1
arrow Cancer Res.  2014 Mar 1;74(5):1506-17. doi: 10.1158/0008-5472.CAN-13-2939. Epub 2014 Jan 3.  PMID: 24390736

62 – Conn PM, Smithson DC, Hodder PS, Stewart MD, Behringer RR, Smith E, Ulloa-Aguirre A, Janovick JA
Transitioning pharmacoperones to therapeutic use: In vivo proof-of-principle and design of high throughput screens
arrow Pharmacol Res.  2014 May;83:38-51. doi: 10.1016/j.phrs.2013.12.004. Epub 2013 Dec 25.  PMID: 24373832

61 – Lewallen DM, Sreelatha A, Dharmarajan V, Madoux F, Chase P, Griffin PR, Orth K, Hodder P, Thompson PR
Inhibiting AMPylation: a novel screen to identify the first small molecule inhibitors of protein AMPylation
arrow ACS Chem Biol.  2014 Feb 21;9(2):433-42. doi: 10.1021/cb4006886. Epub 2013 Nov 25.  PMID: 24274060

60 – Zhou L, Lovell KM, Frankowski KJ, Slauson SR, Phillips AM, Streicher JM, Stahl EL, Schmid CL, Hodder P, Madoux F, Cameron MD, Prisinzano TE, Aube J, Bohn LM
Development of functionally selective, small molecule agonists at kappa opioid receptors
arrow J Biol Chem.  2013 Dec 20;288(51):36703-16. doi: 10.1074/jbc.M113.504381. Epub 2013 Nov 1.  PMID: 24187130

59 – Gentry PR, Kokubo M, Bridges TM, Kett NR, Harp JM, Cho HP, Smith E, Chase P, Hodder PS, Niswender CM, Daniels JS, Conn PJ, Wood MR, Lindsley CW
Discovery of the First M5-Selective and CNS Penetrant Negative Allosteric Modulator (NAM) of a Muscarinic Acetylcholine Receptor: (S)-9b-(4-Chlorophenyl)-1-(3,4-difluorobenzoyl)-2,3-dihydro-1H-imidazo[2,1-a]isoindol-5(9bH)-one (ML375)
arrow J Med Chem.  2013 Nov 27;56(22):9351-5. doi: 10.1021/jm4013246. Epub 2013 Nov 13.  PMID: 24164599

58 – Guerrero M, Poddutoori R, Urbano M, Peng X, Spicer TP, Chase PS, Hodder PS, Schaeffer MT, Brown S, Rosen H, Roberts E
Discovery, design and synthesis of a selective S1P3 receptor allosteric agonist
arrow Bioorg Med Chem Lett.  2013 Dec 1;23(23):6346-9. doi: 10.1016/j.bmcl.2013.09.075. Epub 2013 Oct 1.  PMID: 24135724

57 – Turlington M, Chun A, Tomar S, Eggler A, Grum-Tokars V, Jacobs J, Daniels JS, Dawson E, Saldanha A, Chase P, Baez-Santos YM, Lindsley CW, Hodder P, Mesecar AD, Stauffer SR
Discovery of N-(benzo[1,2,3]triazol-1-yl)-N-(benzyl)acetamido)phenyl) carboxamides as severe acute respiratory syndrome coronavirus (SARS-CoV) 3CLpro inhibitors: Identification of ML300 and noncovalent nanomolar inhibitors with an induced-fit binding
arrow Bioorg Med Chem Lett.  2013 Nov 15;23(22):6172-7. doi: 10.1016/j.bmcl.2013.08.112. Epub 2013 Sep 7.  PMID: 24080461

56 – Richard DJ, Lena R, Bannister T, Blake N, Pierceall WE, Carlson NE, Keller CE, Koenig M, He Y, Minond D, Mishra J, Cameron M, Spicer T, Hodder P, Cardone MH
Hydroxyquinoline-derived compounds and analoguing of selective Mcl-1 inhibitors using a functional biomarker
arrow Bioorg Med Chem.  2013 Nov 1;21(21):6642-6649. doi: 10.1016/j.bmc.2013.08.017. Epub 2013 Aug 15.  PMID: 23993674

55 – Satsu H, Schaeffer MT, Guerrero M, Saldana A, Eberhart C, Hodder P, Cayanan C, Schürer S, Bhhatarai B, Roberts E, Rosen H, Brown SJ
A sphingosine 1-phosphate receptor 2 selective allosteric agonist
arrow Bioorg Med Chem.  2013 Sep 1;21(17):5373-82. doi: 10.1016/j.bmc.2013.06.012. Epub 2013 Jun 15.  PMID: 23849205

54 – Gomes I, Fujita W, Gupta A, Saldanha SA, Negri A, Pinello CE, Eberhart C, Roberts E, Filizola M, Hodder P, Devi LA
Identification of a mu-delta opioid receptor heteromer-biased agonist with antinociceptive activity
arrow Proc Natl Acad Sci U S A.  2013 Jul 16;110(29):12072-7. doi: 10.1073/pnas.1222044110. Epub 2013 Jul 1.  PMID: 23818586

53 – Conn PM, Smith E, Hodder P, Janovick JA, Smithson DC
High-throughput screen for pharmacoperones of the vasopressin type 2 receptor
arrow J Biomol Screen.  2013 Sep;18(8):930-7. doi: 10.1177/1087057113483559. Epub 2013 May 2.  PMID: 23640875

52 – Yang H, Pinello CE, Luo J, Li D, Wang Y, Zhao LY, Jahn SC, Saldanha SA, Chase P, Planck J, Geary KR, Ma H, Law BK, Roush WR, Hodder P, Liao D
Small-molecule inhibitors of acetyltransferase p300 identified by high-throughput screening are potent anticancer agents
arrow Mol Cancer Ther.  2013 May;12(5):610-20. doi: 10.1158/1535-7163.MCT-12-0930. Epub 2013 Apr 26.  PMID: 23625935

51 – Thomas PW, Spicer T, Cammarata M, Brodbelt JS, Hodder P, Fast W
An altered zinc-binding site confers resistance to a covalent inactivator of New Delhi metallo-beta-lactamase-1 (NDM-1) discovered by high-throughput screening
arrow >Bioorg Med Chem.  2013 Jun 1;21(11):3138-46. doi: 10.1016/j.bmc.2013.03.031. Epub 2013 Mar 29.  PMID: 23591260

50 – Karapetyan YE, Sferrazza GF, Zhou M, Ottenberg G, Spicer T, Chase P, Fallahi M, Hodder P, Weissmann C, Lasmézas CI
Unique drug screening approach for prion diseases identifies tacrolimus and astemizole as antiprion agents
arrow Proc Natl Acad Sci U S A.  2013 Apr 23;110(17):7044-9. doi 10.1073/pnas.1303510110.  Epub 2013 Apr 1.  PMID: 23576755

49 – Gentry PR, Bridges TM, Lamasal A, Vinson PN, Smith E, Chase P, Hodder PS, Engers JL, Niswender CM, Scott Daniels J, Jeffrey Conn P, Wood MR, Lindsley CW
Discovery of ML326: The first sub-micromolar, selective M5 PAM
arrow Bioorg Med Chem Lett.  2013 May 15;23(10):2996-3000. doi: 10.1016/j.bmcl.2013.03.032.  Epub 2013 Mar 16.  PMID: 23562060

48 – Nagano JM, Hsu KL, Whitby LR, Niphakis MJ, Speers AE, Brown SJ, Spicer T, Fernandez-Vega V, Ferguson J, Hodder P, Srinivasan P, Gonzalez TD, Rosen H, Bahnson BJ, Cravatt BF
Selective inhibitors and tailored activity probes for lipoprotein-associated phospholipase A(2)
arrow Bioorg Med Chem Lett.  2013 Feb 1;23(3):839-43. doi: 10.1016/j.bmcl.2012.11.061.  Epub 2012 Dec 2.  PMID: 23260346

47 – Jacobs J, Grum-Tokars V, Zhou Y, Turlington M, Saldanha SA, Chase P, Eggler A, Dawson ES, Baez-Santos YM, Tomar S, Mielech AM, Baker SC, Lindsley CW, Hodder P, Mesecar A, Stauffer SR
Discovery, synthesis, and structure-based optimization of a series of N-(tert-Butyl)-2-(N-arylamido)-2-(pyridin-3-yl) acetamides (ML188) as potent noncovalent small molecule inhibitors of the severe acute respiratory syndrome coronavirus (SARS-CoV) 3CL protease
arrow J Med Chem.  2013 Jan 24;56(2):534-46. doi: 10.1021/jm301580n.  Epub 2013 Jan 3.  PMID: 23231439

46 – Qin Q, Knapinska A, Dobri N, Madoux F, Chase P, Hodder P, Petrukhin K
In pursuit of synthetic modulators for the orphan retina-specific nuclear receptor NR2E3
arrow J Ocul Pharmacol Ther.  2013 Apr;29(3):298-309. doi: 10.1089/jop.2012.0.0135.  Epub 2012 Oct 25.  PMID: 23098562

45 – Urbano M, Guerrero M, Zhao J, Velaparthi S, Adrian Saldanha S, Chase P, Wang Z, Civelli O, Hodder P, Schaeffer MT, Brown S, Rosen H, Roberts E
Design, synthesis and SAR analysis of novel potent and selective small molecule antagonists of NPBWR1 (GPR7)
arrow Bioorg Med Chem Lett.  2012 Dec 1;22(23):7135-41. doi: 10.1016/j.bmcl.2012.09.074. Epub 2012 Oct 2.  PMID: 23079522

44 – Adibekian A, Martin BR, Chang JW, Hsu KL, Tsuboi K, Bachovchin DA, Speers AE, Brown SJ, Spicer T, Fernandez-Vega V, Ferguson J, Hodder PS, Rosen H, Cravatt BF
Confirming target engagement for reversible inhibitors in vivo by kinetically tuned activity-based probes
arrow J Am Chem Soc.  2012 Jun 27;134(25):10345-8.  Epub  2012 Jun 12.  PMID: 22690931

43 – Amundsen SK, Spicer T, Karabulut AC, Londoño LM, Eberhart C, Fernandez Vega V, Bannister TD, Hodder P, Smith GR
Small-molecule inhibitors of bacterial AddAB and RecBCD helicase-nuclease DNA repair enzymes
arrow ACS Chem Biol.  2012 May 18;7(5):879-91.  Epub 2012 Mar 23.  PMID: 22443934

42 – Calamini B, Silva MC, Madoux F, Hutt DM, Khanna S, Chalfant MA, Saldanha SA, Hodder P, Tait BD, Garza D, Balch WE, Morimoto RI
Small-molecule proteostasis regulators for protein conformational diseases
arrow Nat Chem Biol.  2011 Dec 25;8(2):185-96. doi: 10.1038/nchembio.763.  PMID: 22198733

41 – Guerrero M, Urbano M, Zhao J, Crisp M, Chase P, Hodder P, Schaeffer MT, Brown S, Rosen H, Roberts E
Discovery, design and synthesis of novel potent and selective sphingosine-1-phosphate 4 receptor (S1P4-R) agonists
arrow Bioorg Med Chem Lett.  2012 Jan 1;22(1):537-42.  Epub 2011 Nov 4.  PMID: 22119461

40 – Roth J, Minond D, Darout E, Liu Q, Lauer J, Hodder P, Fields GB, Roush WR
Identification of novel, exosite-binding matrix metalloproteinase-13 inhibitor scaffolds
arrow Bioorg Med Chem Lett.  2011 Dec 1;21(23):7180-4.  Epub 2011 Sep 22.  PMID: 22018790

39 – Urbano M, Guerrero M, Velaparthi S, Crisp M, Chase P, Hodder P, Schaeffer MT, Brown S, Rosen H, Roberts E
Discovery, synthesis and SAR analysis of novel selective small molecule S1P(4)-R agonists based on a (2Z,5Z)-5-((pyrrol-3-yl)methylene)-3-alkyl-2-(alkylimino)thiazolidin-4-one chemotype
arrow Bioorg Med Chem Lett.  2011 Nov 15;21(22):6739-45.  Epub 2011 Sep 20.  PMID: 21982495

38 – Peatey CL, Spicer T, Hodder P, Trenholme KR, Gardiner DL
A high-throughput assay for the identification of drugs against late-stage Plasmodium falciparum gametocytes
arrow Mol Biochem Parasitol.  2011 Dec;180(2):127-31.  Epub 2011 Sep 16.  PMID: 21939693

37 – Tsuboi K, Bachovchin DA, Speers AE, Spicer TP, Fernandez-Vega V, Hodder P, Rosen H, Cravatt BF
Potent and selective inhibitors of Glutathione S-transferase Omega 1 that impair cancer drug resistance
arrow J Am Chem Soc.  2011 Oct 19;133(41):16605-16.  Epub 2011 Sep 27.  PMID: 21899313

36 – Bialkowska A, Crisp M, Bannister T, He Y, Chowdhury S, Schurer S, Chase P, Spicer T, Madoux F, Tian C, Hodder P, Zaharevitz D, Yang VW
Identification of small-molecule inhibitors of the colorectal cancer oncogene Krüppel-like factor 5 expression by ultrahigh-throughput screening
arrow Mol Cancer Ther.  2011 Nov;10(11):2043-51.  Epub 2011 Sep 1.  PMID: 21885866

35 – Lone AM, Bachovchin D, Westwood D, Speers AE, Spicer TP, Fernandez-Vega V, Chase P, Hodder P, Rosen H, Cravatt BF, Saghatelian A
A substrate-free activity-based protein profiling screen for the discovery of selective PREPL inhibitors
arrow J Am Chem Soc.  2011 Aug 3;133(30):11665-74.  Epub 2011 Jun 21.  PMID: 21692504

34 – Baillargeon P, Scampavia L, Einsteder R, Hodder P
Monitoring of HTS compound library quality via a high-resolution image acquisition and processing instrument
arrow J Lab Autom.  2011 Jun;16(3):197-203. Epub 2011 May 16.   PMID: 21609702

33 – Bachovchin DA, Mohr JT, Speers AE, Wang C, Berlin JM, Spicer TP, Fernandez-Vega V, Chase P, Hodder PS, Schürer SC, Nomura DK, Rosen H, Fu GC, Cravatt BF
Academic cross-fertilization by public screening yields a remarkable class of protein phosphatase methylesterase-1 inhibitors
arrow Proc Natl Acad Sci U S A.  2011 Apr 26;108(17):6811-6. Epub 2011 Mar 11.   PMID: 21398589

32 – Chou TF, Brown SJ, Minond D, Nordin BE, Li K, Jones AC, Chase P, Porubsky PR, Stoltz BM, Schoenen FJ, Patricelli MP, Hodder P, Rosen H, Deshaies RJ
Reversible inhibitor of p97 DBeQ, impairs both ubiquitin-dependent and autophagic protein clearance pathways
arrow Proc Natl Acad Sci U S A.  2011 Mar 22;108(12):4834-9. Epub 2011 Mar 7.   PMID: 21383145

31 – Istrate MA, Spicer TP, Wang Y, Bernard JA, Helvering LM, Bocchinfuso WP, Richardson TI, Zink R, Kumar N, Montrose-Rafizadeh C, Dodge J, Hodder P, Griffin PR
Development of an HTS-compatible assay for discovery of ROR? modulators using AlphaScreen® technology
arrow J Biomol Screen.  2011 Feb;16(2):183-91.  PMID: 21297105

30 – Doghman M, Madoux F, Hodder P, Lalli E
Identification and characterization of steroidogenic factor-1 inverse agonists
arrow Methods Enzymol.  2010;485:3-23.  PMID: 21050908

29 – Madoux F, Simanski S, Chase P, Mishra JK, Roush WR, Ayad NG, Hodder PS
An ultra-high throughput cell-based screen for Wee1 degradation inhibitors
arrow J Biomol Screen.  2010 Sep;15(8):907-17. Epub 2010 Jul 26.  PMID: 20660794

28 – Weide T, Saldanha SA, Minond D, Spicer TP, Fotsing JR, Spaargaren M, Frère JM, Bebrone C, Sharpless KB, Hodder P, Fokin VV
NH-1,2,3-triazole-based inhibitors of the VIM-2 metallo-beta-lactamase: synthesis and structure-activity studies.
arrow ACS Med Chem Lett.  2010 Jul 8;1(4):150-154.  PMID: 20625539

27 – Brunell D, Weissbach H, Hodder P, Brot N
A high-throughput screening compatible assay for activators and inhibitors of methionine sulfoxide reductase A
arrow Assay Drug Dev Technol.  2010 Oct;8(5):615-20.  Epub 2010 Jun 1.  PMID: 20515413

26 – Bachovchin DA, Wolfe MR, Masuda K, Brown SJ, Spicer TP, Fernandez-Vega V, Chase P, Hodder PS, Rosen H, Cravatt BF
Oxime esters as selective, covalent inhibitors of the serine hydrolase retinoblastoma-binding protein 9 (RBBP9)
arrow Bioorg Med Chem Lett.  2010 Apr 1;20(7):2254-8.  Epub 2010 Feb 6.  PMID: 20207142

25 – Grimm C, Jörs S, Saldanha SA, Obukhov AG, Pan B, Oshima K, Cuajungco MP, Chase P, Hodder P, Heller S
Small molecule activators of TRPML3
arrow Chem Biol.  2010 Feb 26;17(2):135-48.  PMID: 20189104

24 – Tanaka K, Koresawa M, Iida M, Fukasawa K, Stec EM, Cassaday J, Chase P, Rickert K, Hodder P, Takagi T, Komatani H
Multiplexed random peptide library and phospho-specific antibodies facilitate human polo-like kinase 1 inhibitor screen
arrow Assay Drug Dev Technol.  2010 Feb;8(1):47-62.  PMID: 20085455

23 – Kota S, Scampavia L, Spicer T, Beeler AB, Takahashi V, Snyder JK, Porco JA, Hodder P, Strosberg AD
A time-resolved fluorescence-resonance energy transfer assay for identifying inhibitors of hepatitis C virus core dimerization
arrow Assay Drug Dev Technol.  2010 Feb;8(1):96-105.  PMID: 20035614

22 – Brothers SP, Saldanha SA, Spicer TP, Cameron M, Mercer BA, Chase P, McDonald P, Wahlestedt C, Hodder PS
Selective and brain penetrant neuropeptide Y Y2 receptor antagonists discovered by whole-cell high-throughput screening
arrow Mol Pharmacol.  2010 Jan;77(1):46-57.  Epub 2009 Oct 16.  PMID: 19837904

21 – Minond D, Saldanha SA, Subramaniam P, Spaargaren M, Spicer T, Fotsing JR, Weide T, Fokin VV, Sharpless KB, Galleni M, Bebrone C, Lassaux P, Hodder P
Inhibitors of VIM-2 by screening pharmacologically active and click-chemistry compound libraries
arrow Bioorg Med Chem.  2009 Jul 15;17(14):5027-37.  Epub 2009 Jun 22.  PMID: 19553129

20 – Doghman M, Cazareth J, Douguet D, Madoux F, Hodder P, Lalli E
Inhibition of adrenocortical carcinoma cell proliferation by steroidogenic factor-1 inverse agonists
arrow J Clin Endocrinol Metab.  2009 Jun;94(6):2178-83.  Epub 2009 Mar 24.  PMID: 19318454

19 – Schürer SC, Brown SJ, Gonzalez-Cabrera PJ, Schaeffer MT, Chapman J, Jo E, Chase P, Spicer T, Hodder P, Rosen H
Ligand-binding pocket shape differences between sphingosine 1-phosphate (S1P) receptors S1P1 and S1P3 determine efficiency of chemical probe identification by ultrahigh-throughput screening
arrow ACS Chem Biol.  2008 Aug 15;3(8):486-98.  Epub 2008 Jul 1.  PMID: 18590333

18 – Chung CC, Ohwaki K, Schneeweis JE, Stec E, Varnerin JP, Goudreau PN, Chang A, Cassaday J, Yang L, Yamakawa T, Kornienko O, Hodder P, Inglese J, Ferrer M, Strulovici B, Kusunoki J, Tota MR, Takagi T
A fluorescence-based thiol quantification assay for ultra-high-throughput screening for inhibitors of coenzyme A production
arrow Assay Drug Dev Technol.  2008 Jun;6(3):361-74.  PMID: 18452391

17 – Roth J, Madoux F, Hodder P, Roush WR
Synthesis of small molecule inhibitors of the orphan nuclear receptor steroidogenic factor-1 (NR5A1) based on isoquinolinone scaffolds
arrow Bioorg Med Chem Lett.  2008 Apr 15;18(8):2628-32.  Epub 2008 Mar 14.  PMID: 18374567

16 – Lauer-Fields JL, Minond D, Chase PS, Baillargeon PE, Saldanha SA, Stawikowska R, Hodder P, Fields GB
High throughput screening of potentially selective MMP-13 exosite inhibitors utilizing a triple-helical FRET substrate
arrow Bioorg Med Chem.  2009 Feb 1;17(3):990-1005.  Epub 2008 Mar 6.  PMID: 18358729

15 – Madoux F, Li X, Chase P, Zastrow G, Cameron MD, Conkright JJ, Griffin PR, Thacher S, Hodder P
Potent, selective and cell penetrant inhibitors of SF-1 by functional ultra-high-throughput screening
arrow Mol Pharmacol.  2008 Jun;73(6):1776-84.  Epub 2008 Mar 11.  PMID: 18334597

14 – Schröter T, Minond D, Weiser A, Dao C, Habel J, Spicer T, Chase P, Baillargeon P, Scampavia L, Schürer S, Chung C, Mader C, Southern M, Tsinoremas N, LoGrasso P, Hodder P
Comparison of miniaturized time-resolved fluorescence resonance energy transfer and enzyme-coupled luciferase high-throughput screening assays to discover inhibitors of rho-kinase II (ROCK-II)
arrow J Biomol Screen.  2008 Jan;13(1):17-28.  PMID: 18227223

13 – Lauer-Fields JL, Spicer TP, Chase PS, Cudic M, Burstein GD, Nagase H, Hodder P, Fields GB
Screening of potential a disintegrin and metalloproteinase with thrombospondin motifs-4 inhibitors using a collagen model fluorescence resonance energy transfer substrate
arrow Anal Biochem.  2008 Feb 1;373(1):43-51.  Epub 2007 Sep 15.  PMID: 17949675

12 – Marine S, Stec E, Chase P, Hoffman I, Szymanski S, Simon A, Shi X, Bartz S, Bagchi A, Minch E, Majercak J, Koblan K, Hazuda D, Shearman M, Gates A, Xu M, Rosahl T, Beher D, Ray W, Stone D, Espeseth A, Ferrer M, Strulovici B
Activity profile-based siRNA screen to explore the functional genomics of Alzheimer’s disease
arrow BioTechniques.  2007 Dec;43(6):Sxxii-Sxxvii. ARTICLE.

11 – Hodder PS
Building a uHTS laboratory
arrow Drug Discovery World.  2005 Winter;6:31-42. ARTICLE.

10 – Hodder PS
Integration of miniaturisation technologies into the high throughput screening laboratory
European Pharmaceutical Review.  2005 May 20;2:47-55

9 – Zuck P, O’Donnell GT, Cassaday J, Chase P, Hodder P, Strulovici B, Ferrer M
Miniaturization of absorbance assays using the fluorescent properties of white microplates
arrow Anal Biochem.  2005 Jul 15;342(2):254-9.  PMID: 15949786

8 – Hale JJ, Lynch CL, Neway W, Mills SG, Hajdu R, Keohane CA, Rosenbach MJ, Milligan JA, Shei GJ, Parent SA, Chrebet G, Bergstrom J, Card D, Ferrer M, Hodder P, Strulovici B, Rosen H, Mandala S
A rational utilization of high-throughput screening affords selective, orally bioavailable 1-benzyl-3-carboxyazetidine sphingosine-1-phosphate-1 receptor agonists
arrow J Med Chem.  2004 Dec 30;47(27):6662-5.  PMID: 15615513

7 – Hodder P, Mull R, Cassaday J, Berry K, Strulovici B
Miniaturization of intracellular calcium functional assays to 1536-well plate format using a fluorometric imaging plate reader
arrow J Biomol Screen.  2004 Aug;9(5):417-26.  PMID: 15296641

6 – Kunapuli P, Ransom R, Murphy KL, Pettibone D, Kerby J, Grimwood S, Zuck P, Hodder P, Lacson R, Hoffman I, Inglese J, Strulovici B
Development of an intact cell reporter gene beta-lactamase assay for G protein-coupled receptors for high-throughput screening
arrow Anal Biochem.  2003 Mar 1;314(1):16-29.  PMID: 12633598

5 – Hodder P, Cassaday J, Peltier R, Berry K, Inglese J, Feuston B, Culberson C, Bleicher L, Cosford ND, Bayly C, Suto C, Varney M, Strulovici B
Identification of metabotropic glutamate receptor antagonists using an automated high throughput screening system
arrow Anal Biochem.  2003 Feb 15;313(2):246-54.  PMID: 12605861

4 – Hodder PS, Beeson C, Ruzicka J
Equilibrium and kinetic measurement of muscarinic receptor antagonism on living cells using bead injection spectroscopy
arrow Anal Chem.  2000 Jul 15;72(14):3109-15.  PMID: 10939374

3 – Scampavia LD, Hodder PS, Lähdesmäki I, Ruzicka J
Automation of functional assays by flow injection fluorescence microscopy
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